Author

C. Merle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

S. Fre· 2 shared A. Velds· 1 shared A. Walczak· 1 shared A. Wurmser· 1 shared B. Bui· 1 shared C. Chevreau· 1 shared C. Conrad· 1 shared D. Loew· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

S. Fre

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: A revision of the prohypertrophic signalling network concept

S. Diederichs, S. I. Dreher, S.-A. Nueesch, S. Schmidt, C. Merle, W. Richter

This study investigates the role of ALK1/2/3 inhibition in mesenchymal stromal cell chondrogenesis, finding that BMP-ALK1/2/3 signaling is not a driver of hypertrophy and that PTHrP/hedgehog and WNT signaling are more critical in hypertrophic differentiation.

bioRxiv · Mar 12, 2024Cell Biology

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

J. Urbanus, J. Cosgrove, J. Beltman, Y. Elhanati, R. De Andrade Moral, C. Conrad, J. Van Heijst, E. Tubeuf, A. Velds, L. Kok, C. Merle, J. P. Magnusson, J. Frisen, S. Fre, A. Walczak, , L. Perie

This study uses an in situ lineage tracing method to show that aging increases the number of HSPCs contributing to myelopoiesis, not their individual output.

bioRxiv · Dec 6, 2022 · PreprintImmunology

Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

G. Jacquemin, A. Wurmser, M. Huyghe, W. Sun, Z. Homayed, C. Merle, F. Qasrawi, M. Perkins, S. Richon, F. Dingli, G. Arras, D. Loew, D. Vignjevic, J. Pannequin, S. Fre

This study identifies THBS1-YAP signaling as a paracrine mechanism that reprograms healthy intestinal epithelial cells to support tumor growth.

bioRxiv · Dec 16, 2020Cancer Biology

Distinct cellular origins and differentiation process account for distinct oncogenic and clinical behaviors of leiomyosarcomas

E. Darbo, G. Perot, L. Darmusey, S. Le Guellec, L. Leroy, L. Gaston, N. Desplat, N. Thebault, C. Merle, P. Rochaix, T. Valentin, G. Ferron, C. Chevreau, B. Bui, E. Stoeckle, , F. Chibon

The paper identifies a transcriptionally homogeneous subgroup of leiomyosarcomas originating from vascular smooth muscle cells and explains their unique oncogenic behavior through specific pathway alterations.

bioRxiv · Oct 23, 2020Cancer Biology