Deletion of Mcpip1 in Mcpip1AlbKO mice recapitulates the phenotype of human primary biliary cholangitis
J. Kotlinowski, T. Hutsch, I. Czyzynska-Cichon, M. Wadowska, N. Pydyn, A. Jasztal, A. Kij, E. Dobosz, M. Lech, K. Miekus, E. Pospiech, M. Fu, J. Jura, J. Koziel, S. Chlopicki
This paper shows that deleting Mcpip1 in liver-specific mice (Mcpip1AlbKO) causes a PBC-like disease, with features similar to human primary biliary cholangitis, including fibrosis, inflammation, and autoantibodies.
bioRxiv · Sep 5, 2020Pathology