Author

M. Lech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

A. Casimiro-Garcia· 1 shared A. Jasztal· 1 shared A. Kij· 1 shared B. G. Johnson· 1 shared B. Zhang· 1 shared E. Dobosz· 1 shared E. Pospiech· 1 shared F. J. Schlerman· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Casimiro-Garcia

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Pharmacologic inhibition of Protein Kinase C α and Protein Kinase C β halts renal function decline indirectly, by blunting hyperphagia, and directly reduces adiposity in the ZSF1 rat model of type 2 diabetes

J. Wang, A. Casimiro-Garcia, B. G. Johnson, J. Duffen, M. Cain, L. Savary, S. Wang, P. Nambiar, M. Lech, S. Zhao, L. Xi, Y. Zhan, J. Olson, J. A. Stejskal, H. Lin, , K. Dower

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

bioRxiv · Dec 2, 2020 · PreprintPharmacology & Toxicology

Deletion of Mcpip1 in Mcpip1AlbKO mice recapitulates the phenotype of human primary biliary cholangitis

J. Kotlinowski, T. Hutsch, I. Czyzynska-Cichon, M. Wadowska, N. Pydyn, A. Jasztal, A. Kij, E. Dobosz, M. Lech, K. Miekus, E. Pospiech, M. Fu, J. Jura, J. Koziel, S. Chlopicki

This paper shows that deleting Mcpip1 in liver-specific mice (Mcpip1AlbKO) causes a PBC-like disease, with features similar to human primary biliary cholangitis, including fibrosis, inflammation, and autoantibodies.

bioRxiv · Sep 5, 2020Pathology