Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression
J. M. DeBlasi, A. Falzone, S. Caldwell, N. Prieto-Farigua, J. R. Prigge, E. E. Schmidt, I. I. C. Chio, F. A. Karreth, G. M. DeNicola
This study investigates the role of Nrf2 signaling thresholds in lung tumor initiation and progression using murine models with KEAP1 and NRF2 mutations.
bioRxiv · Aug 24, 2022Cancer Biology