F. A. Karreth

This study shows PTEN's lipid phosphatase activity suppresses melanoma by inhibiting AKT/mTOR signaling and reducing FRA1 expression.

This study investigates the role of Nrf2 signaling thresholds in lung tumor initiation and progression using murine models with KEAP1 and NRF2 mutations.

The paper shows that chromosome 1q amplification promotes melanoma metastasis by overexpressing ceRNAs that sequester tumor suppressor miRNAs.

This study shows that MAPK-induced miR-29 suppresses melanoma by targeting MAFG, and its inactivation accelerates tumor development.

This study shows PHGDH depletion in adult mice is tolerated, with normal liver and pancreatic function, but reduced PHGDH leads to altered lipid homeostasis in the liver.

This paper develops an ESC-based melanoma mouse model platform to rapidly generate genetically engineered mice for melanoma research using multiple genetic strategies.