Author

A. Falzone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

G. M. DeNicola· 6 shared F. A. Karreth· 2 shared J. M. DeBlasi· 2 shared L. Torrente· 2 shared N. P. Ward· 2 shared N. Prieto-Farigua· 2 shared S. Caldwell· 2 shared Y. P. Kang· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersCancer Biology

G. M. DeNicola

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6 papers

Recent·Most cited

Imaging the master regulator of the antioxidant response in non-small cell lung cancer with positron emission tomography

H. E. Greenwood, R. S. Edwards, W. E. Tyrrell, A. R. Barber, F. Baark, M. Tanc, E. Khalil, A. Falzone, N. P. Ward, J. M. DeBlasi, L. Torrente, D. R. Pearce, G. Firth, L. M. Smith, O. Vilhelmsson Timmermand, , T. H. Witney

This study uses PET imaging to assess NRF2 activation in NSCLC, showing [18F]FSPG as a marker of therapeutic resistance and a potential target for treatment.

bioRxiv · Dec 16, 2023Cancer Biology

The Origin Of Cysteine and its Catabolism in Mammalian Tissues and Tumors

S. J. Yoon, J. A. Combs, A. Falzone, N. Prieto-Farigua, S. Caldwell, H. D. Ackerman, E. R. Flores, G. M. DeNicola

This study investigates cysteine metabolism in normal and tumor tissues using isotopic tracing, finding that cystine uptake is universal while de novo synthesis and catabolism vary across tissues and tumor types.

bioRxiv · Aug 26, 2022Cancer Biology

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

J. M. DeBlasi, A. Falzone, S. Caldwell, N. Prieto-Farigua, J. R. Prigge, E. E. Schmidt, I. I. C. Chio, F. A. Karreth, G. M. DeNicola

This study investigates the role of Nrf2 signaling thresholds in lung tumor initiation and progression using murine models with KEAP1 and NRF2 mutations.

bioRxiv · Aug 24, 2022Cancer Biology

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone

L. Torrente, N. Prieto, A. Falzone, D. A. Boothman, E. B. Haura, G. M. DeNicola

This study shows that NRF2/KEAP1 mutations confer resistance to β-lapachone by enhancing ROS detoxification, and that inhibiting SOD1 or the thioredoxin system can overcome this resistance.

bioRxiv · Nov 25, 2019Cancer Biology

PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

Y. P. Kang, A. Falzone, M. Liu, J. J. Saller, F. A. Karreth, G. M. DeNicola

This study shows PHGDH depletion in adult mice is tolerated, with normal liver and pancreatic function, but reduced PHGDH leads to altered lipid homeostasis in the liver.

bioRxiv · Nov 12, 2019Biochemistry

NNT Regulates Mitochondrial Metabolism in NSCLC Through Maintenance of Fe-S Protein Function

N. P. Ward, Y. P. Kang, A. Falzone, T. A. Boyle, G. M. DeNicola

This study shows NNT promotes NSCLC tumor growth by maintaining Fe-S protein function through NADPH production, preventing mitochondrial dysfunction and ROS accumulation.

bioRxiv · Sep 6, 2019Cancer Biology