Tubulin engineering by semisynthesis reveals that polyglutamylation directs detyrosination
E. Ebberink, S. Fernandes, G. Hatzopoulos, N. Agashe, N. Guidotti, T. M. Reichart, L. Reymond, M. C. Velluz, C. Pourroy, C. Janke, P. Gonczy, B. Fierz, C. Aumeier
This study uses chemical synthesis to create tubulins with defined PTMs, revealing that polyglutamylation promotes detyrosination by enhancing vasohibin/SVBP activity.
bioRxiv · Sep 20, 2022Biochemistry