Author

B. Fierz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 5 Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 2 Assay:protein structure· 2 Assay:ChIP-seq· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. Trono· 2 shared R. Hovius· 2 shared A. Borgia· 1 shared A. Kalantzi· 1 shared A. M. Stachowicz· 1 shared A. Marchand· 1 shared A. Petruzzella· 1 shared A. Scheck· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBioengineering

D. Trono

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Tubulin engineering by semisynthesis reveals that polyglutamylation directs detyrosination

E. Ebberink, S. Fernandes, G. Hatzopoulos, N. Agashe, N. Guidotti, T. M. Reichart, L. Reymond, M. C. Velluz, C. Pourroy, C. Janke, P. Gonczy, B. Fierz, C. Aumeier

This study uses chemical synthesis to create tubulins with defined PTMs, revealing that polyglutamylation promotes detyrosination by enhancing vasohibin/SVBP activity.

bioRxiv · Sep 20, 2022Biochemistry

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

H. Nagpal, B. Fierz

This study shows CENP-A and CENP-B collaborate to create an open centromeric chromatin state through dynamic interactions and structural changes.

bioRxiv · Jul 8, 2022Biophysics

De novo design of site-specific protein interactions with learned surface fingerprints

P. Gainza, S. Wehrle, A. Van Hall-Beauvais, A. Marchand, A. Scheck, Z. Harteveld, D. Ni, S. Tan, F. Sverrisson, C. Goverde, P. Turelli, C. Raclot, A. Teslenko, M. Pacesa, S. Rosset, , B. E. Correia

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

bioRxiv · Jun 16, 2022 · PreprintBioengineering

Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1

N. Luithle, J. uit de Bos, R. Hovius, D. Maslennikova, R. Lewis, R. Ungricht, B. Fierz, U. Kutay

This study shows that Torsin ATPases regulate LAP1's chromatin interaction, affecting mitotic chromosome segregation and nuclear morphology.

bioRxiv · Oct 1, 2020Cell Biology

Disordered Proteins Enable Histone Chaperoning on the Nucleosome

P. O. Heidarsson, D. Mercadante, A. Sottini, D. Nettels, M. B. Borgia, A. Borgia, S. Kilic, B. Fierz, R. B. Best, B. Schuler

The paper shows that disordered regions in proteins like H1 enable competitive displacement by histone chaperones such as prothymosin on the nucleosome.

bioRxiv · Apr 17, 2020Biophysics

The mechanistic basis for chromatin invasion and remodeling by the yeast pioneer transcription factor Rap1

M. Mivelaz, A.-M. Cao, S. Kubik, S. Zencir, R. Hovius, I. Boichenko, A. M. Stachowicz, C. F. Kurat, D. Shore, B. Fierz

This study reveals how the yeast pioneer transcription factor Rap1 invades and remodels chromatin by opening fiber structure and collaborating with RSC to destabilize promoter nucleosomes.

bioRxiv · Jul 9, 2019Biophysics

KAP1 is an antiparallel dimer with a natively functional asymmetry

G. Fonti, M. Marcaida, L. Bryan, S. Traeger, A. Kalantzi, P.-Y. Helleboid, D. Demurtas, M. Tully, S. Grudinin, D. Trono, B. Fierz, M. Dal Peraro

This paper shows KAP1 forms an antiparallel dimer with a native asymmetry, which affects its SUMOylation and interaction with HP1.

bioRxiv · Feb 19, 2019Biophysics