C. Janke

Glutamylation imbalance leads to photoreceptor degeneration

This study shows that glutamylation imbalance in photoreceptor cells leads to structural defects and degeneration, highlighting its role in maintaining outer segment architecture.

Tau phosphorylation impedes functionality of protective tau envelopes

This study shows that tau phosphorylation impairs the protective function of tau envelopes, leading to microtubule destabilization in neurodegenerative disorders.

Polyglutamylation of microtubules drives neuronal remodeling

The paper shows that polyglutamylation of microtubules regulates neuronal remodeling by marking them for severing, affecting synapse and axon pruning in both peripheral and central circuits.

A new mechanism of posttranslational polyglutamylation regulates phase separation and signaling of the Wnt pathway protein Dishevelled.

The paper identifies TTLL11-mediated polyglutamylation of DVL3 as a novel modification that regulates its phase separation and signaling in the non-canonical Wnt pathway.

Elongator is a microtubule polymerase selective for poly-glutamylated tubulin

This paper identifies Elongator's role in stabilizing microtubules by selectively binding polyglutamylated tubulin, contributing to cell fate determination during asymmetric division.

MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement

This study identifies MAP9/MAPH-9 as a conserved protein supporting axonemal microtubule doublets and modulating ciliary motor function in C. elegans and mammals.

Tubulin engineering by semisynthesis reveals that polyglutamylation directs detyrosination

This study uses chemical synthesis to create tubulins with defined PTMs, revealing that polyglutamylation promotes detyrosination by enhancing vasohibin/SVBP activity.

VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules

This paper shows VASH1-SVBP and VASH2-SVBP generate distinct detyrosination patterns on microtubules through different molecular mechanisms.

Genetically encoded live cell sensor for tyrosinated microtubules

The paper develops a genetically encoded live cell sensor for tyrosinated microtubules and uses it to study drug-induced microtubule depolymerization.

Partial loss of colonic primary cilia promotes inflammation and carcinogenesis

This study shows that reduced colonic primary cilia in fibroblasts promotes inflammation and cancer in mouse models and human disease.

Spindle asymmetry drives non-Mendelian chromosome segregation

The paper shows that spindle asymmetry, regulated by CDC42 signaling and microtubule tyrosination, enables non-Mendelian chromosome segregation during female meiosis.