Suppression of endothelial miR-22-3p mediates non-small cell lung cancer cell-induced angiogenesis
Y. Gu, G. Pais, V. Becker, C. Körbel, E. Ampofo, E. Ebert, J. Hohneck, N. Ludwig, E. Meese, R. M. Bohle, Y. Zhao, M. D. Menger, M. W. Laschke
The paper shows that reduced endothelial miR-22-3p in NSCLC tissues promotes angiogenesis by inhibiting SIRT1 and FGFR1, leading to AKT/mTOR inactivation and tumor growth.
bioRxiv · Apr 4, 2021Cancer Biology