Y. Gu

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF-κB signaling

Controlled and orthogonal partitioning of large particles into biomolecular condensates

This study demonstrates that large particles can be controlled and orthogonally partitioned into biomolecular condensates through strong particle-condensate interactions, using polymer nanoparticles with tailored surface chemistries.

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

Pooled CRISPR interference screening identifies crucial transcription factors in gas-fermenting Clostridium ljungdahlii

This study uses CRISPRi screening to identify transcription factors crucial for growth and carbon utilization in Clostridium ljungdahlii, improving ethanol production through deoR optimization.

Efficacy of an oral lipid nanocrystal (LNC) formulation of amphotericin B (MAT2203) in the neutropenic mouse model of pulmonary mucormycosis

This study compares the efficacy of oral MAT2203 to intravenous LAMB in a neutropenic mouse model of mucormycosis, finding MAT2203 as effective in survival and fungal burden reduction.

Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

This study determines the structure of SCARF1 and identifies its ligand recognition mechanism, revealing key residues and shared binding sites for modified LDLs and bacterial teichoic acids.

IL-1B-mediated inflammatory signaling drives ineffective erythropoiesis in early-stage myelodysplastic syndromes

This study shows that IL-1B-mediated inflammation drives ineffective erythropoiesis in early-stage MDS and that canakinumab can reduce transfusion dependence in patients with DNMT3A and TET2 mutations.

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.

Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains

The paper identifies the structural basis for activation of Bacillus cereus Shedu nuclease and reveals diversity in its N-terminal regulatory domains across 8,000 homologs.

A conserved and druggable pocket in class B G protein coupled receptors for orally active small molecule agonists

This study identifies a conserved binding pocket in class B GPCRs that enables small molecule agonists like PCO371 to activate G proteins without triggering arrestin signaling.

Identification of the bacteriophage nucleus protein interaction network

The paper identifies proteins interacting with the phage nucleus protein ChmA and describes their potential roles in genome packaging and transport.

RNA Sensing and Innate Immunity Constitutes a Barrier for Interspecies Chimerism

This study identifies RNA sensing and innate immunity in host embryos as a barrier to interspecies chimerism and shows that modifying host embryos can enhance human cell survival in chimeric embryos.

Peroxisomal compartmentalization of amino acid biosynthesis reactions imposes an upper limit on compartment size

The paper investigates how peroxisomal compartmentalization of amino acid biosynthesis reactions affects compartment size and redox balance in fission yeast.

Chromatin binding by HORMAD proteins regulates meiotic recombination initiation

This study shows that HORMAD proteins bind chromatin to regulate meiotic recombination initiation in yeast.

Spatial transcriptomic atlas of shoot organogenesis in tomato callus

This study creates a spatial transcriptomic atlas of tomato callus during shoot regeneration, identifying cell types and developmental trajectories.

High-throughput screening of functional neo-antigens and their specific TCRs via the Jurkat reporter system combine with droplet microfluidics

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

CALCIUM-DEPENDENT PROTEIN KINASE32 regulates cellulose biosynthesis through post-translational modification of cellulose synthase

The paper identifies CPK32 as a kinase that phosphorylates CESA3, affecting CSC motility and stability, thereby regulating cellulose biosynthesis.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses

This study shows that intestinal epithelial cells expressing MHC II modulate CD4 T cell responses during intestinal inflammation, dampening pro-inflammatory effector Th cells.

Optimization of energy production and central carbon metabolism in a non-respiring eukaryote

This study compares metabolic strategies in two fission yeasts, showing how S. japonicus optimizes central carbon metabolism through glycerol-3-phosphate synthesis, a bifurcated TCA cycle, and the pentose phosphate pathway for higher ATP production.

Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery

This paper discovers Vibrio natriegens as a microbial platform for efficient formic acid utilization and remodeled it to enhance formate consumption and indigoidine production.

CotH genes are necessary for normal spore formation and virulence in Mucor lusitanicus

This study identifies CotH genes in Mucor lusitanicus and shows their role in spore formation, virulence, and cell wall structure through CRISPR-Cas9 disruption and infection models.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

Modeling Microtubule-Cytoplasm Interaction in Plant Cells

The paper develops a computational model to study microtubule-cytoplasm interaction in plant cells, showing microtubules align orthogonally to cell elongation and matching experimental results.

A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

The paper identifies a conserved population of MHC-II restricted, innate-like T cells in the gut of humans and mice that react to commensals and are implicated in colitis.

Droplet microfluidics forward for tracing target cells at single-cell transcriptome resolution

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

Intestinal lamina propria supports acquired eTreg suppressor function

This study identifies spatially compartmentalized Treg subsets in the gut, showing that lamina propria supports acquired eTreg suppressor function through specific interactions with IL-1β+ macrophages and ILC2.

Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.

This study shows that loss of obscurin and Obsl1 in mice causes diastolic dysfunction, altered metabolism, and deregulated mitophagy in the heart.

Towards 3D-bioprinting of osseous tissue of pre-defined shape using single-matrix cell-bioink constructs

This study demonstrates 3D-bioprinting of bone-like tissue with predefined shapes using a single-matrix bioink, showing retention of shape and endochondral ossification in vivo.

Metabolomics and transcriptomics reveal the response mechanisms of Mikania micrantha to Puccinia spegazzinii infection

This study investigates how Mikania micrantha responds to Puccinia spegazzinii infection using metabolomics and transcriptomics, identifying changes in metabolites and gene expression.