Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation
E. Erickson, I. You, G. Perry, A. Dugourd, K. Donovan, C. Crafter, J. Johannes, S. Williamson, J. Moss, S. Ros, R. Ziegler, S. Barry, E. Fischer, N. Gray, R. Madsen, A. Toker
This study develops a second-generation AKT degrader, INY-05-040, showing improved efficacy over existing inhibitors in breast cancer cells by inducing stress MAPK signaling.
bioRxiv · Oct 11, 2022 · PreprintCancer Biology