E. S. Fischer

Molecular mechanism of Mad2 conformational conversion promoted by the Mad2-interaction motif of Cdc20

This study elucidates how the Cdc20MIM induces Mad2 conformational conversion by transiently exposing a binding site and facilitating structural changes.

Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues

This study evaluates how electrophilic modifications to JQ1 affect DCAF16 trans-labeling and BRD4 degradation, showing a correlation between warhead exposure and degradation efficiency.

HDAC6/aggresome processing pathway importance for inflammasome formation is context dependent

The study shows that HDAC6's role in inflammasome formation varies depending on the cellular context and model system used.

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

This paper describes a new mechanism for molecular glue degraders called template-assisted covalent modification, showing how BRD4 degraders recruit CUL4DCAF16 to degrade BRD4.

Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly

This study investigates how Mps1 phosphorylation of Mad1 facilitates the assembly of the mitotic checkpoint complex by promoting interactions between Mad1, Cdc20, and Bub1.

Development and utility of a PAK1-selective degrader

This study develops a PAK1-selective degrader, BJG-05-039, which shows enhanced anti-proliferative effects compared to the parent inhibitor NVS-PAK1-1 in PAK1-dependent cell lines.

Proteolysis Targeting Chimeras With Reduced Off-targets

This study develops a platform to identify off-target degradation of ZF proteins by PROTACs and identifies design rules to reduce off-target effects using pomalidomide analogs.

Targeted degradation of the oncogenic phosphatase SHP2

This paper develops a SHP2 PROTAC that degrades SHP2 in leukemic cells, inhibits MAPK signaling, and suppresses cancer growth.

Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19

The paper profiles early humoral immune responses in COVID-19 patients, finding that survivors show rapid SARS-CoV-2-specific immunity linked to pre-existing OC43 immunity, while non-survivors have delayed and blunted responses.

Discovery of an AKT Degrader with Prolonged Inhibition ofDownstream Signaling

This study develops INY-03-041, a pan-AKT degrader that shows prolonged inhibition of AKT and downstream signaling effects compared to traditional inhibitors.

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

The paper reveals how E7820 promotes RBM39 degradation via DCAF15 by binding to a non-conserved pocket on DCAF15, bypassing the need for high-affinity ligands.