Potassium dependent structural changes in the selectivity filter of HERG potassium channels
C. H. Lau, E. Flood, M. J. Hunter, B. J. Williams-Noonan, K. M. Corbett, C.-A. Ng, J. C. Bouwer, A. G. Stewart, E. Perozo, T. W. Allen, J. I. Vandenberg
The paper determines structures of conductive and non-conductive HERG selectivity filters and identifies a mechanism for rapid inactivation kinetics.
bioRxiv · Dec 14, 2023Biophysics