Author

E. Perozo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:protein folding & dynamics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Approach:mechanistic / dynamical model· 2 Assay:structural biology· 2

Frequent Co-Authors

R. Shen· 3 shared A. Barreiro· 2 shared A. Fernandez· 2 shared A. Moros· 2 shared B. Roux· 2 shared C. Garriga· 2 shared E. Pradenas· 2 shared J. Blanco· 2 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

R. Shen

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Structural Basis of Voltage-Dependent Gating in BK Channels and Its Coupling to the Calcium Sensor

G. F. Contreras, R. Shen, R. Latorre, E. Perozo

This study uses cryo-EM to examine BK channel structures with locked voltage sensor states, revealing how voltage and calcium binding interact to control channel gating.

bioRxiv · Dec 29, 2023 · PreprintBiophysics

Potassium dependent structural changes in the selectivity filter of HERG potassium channels

C. H. Lau, E. Flood, M. J. Hunter, B. J. Williams-Noonan, K. M. Corbett, C.-A. Ng, J. C. Bouwer, A. G. Stewart, E. Perozo, T. W. Allen, J. I. Vandenberg

The paper determines structures of conductive and non-conductive HERG selectivity filters and identifies a mechanism for rapid inactivation kinetics.

bioRxiv · Dec 14, 2023Biophysics

Conformation-specific synthetic antibodies discriminate multiple functional states of the ion channel CorA

S. K. Erramilli, P. K. Dominik, D. Deneka, P. P. Tokarz, S. S. Kim, B. G. Reddy, B. M. Skrobek, O. Dalmas, E. Perozo, A. A. Kossiakoff

This study uses synthetic antibodies to identify and characterize different conformational states of the CorA ion channel under varying magnesium conditions.

bioRxiv · May 7, 2023Biochemistry

Folding of Prestin's Anion-Binding Site and the Mechanism of Outer Hair Cell Electromotility

X. Lin, P. Haller, N. Bavi, N. Faruk, E. Perozo, T. Sosnick

This study investigates how Prestin's anion-binding site folding drives its voltage-sensitive conformational changes, revealing a unique mechanism for outer hair cell electromotility.

bioRxiv · Feb 27, 2023Biophysics

Immunogenicity and safety in pigs of PHH-1V, a SARS-CoV-2 RBD fusion heterodimer vaccine candidate

A. Moros, A. Prefaneta, A. Barreiro, E. Perozo, A. Fernandez, M. Canete, L. Gonzalez, C. Garriga, E. Pradenas, S. Marfil, J. Blanco, P. Cebollada-Rica, M. Sistere-Oro, A. Meyerhans, T. Prat Cabanas, , L. Ferrer

This study evaluates the immunogenicity and safety of PHH-1V, a SARS-CoV-2 RBD fusion vaccine in pigs, showing a robust immune response and good safety profile.

bioRxiv · Jan 19, 2023Immunology

State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels

Y. C. Park, B. Reddy, N. Bavi, E. Perozo, J. D. Faraldo-Gomez

This paper investigates how lipid bilayer deformations influence the gating of MscS ion channels, showing that tension shifts the equilibrium by increasing the energy cost of closed-state membrane protrusions.

bioRxiv · Jul 1, 2022Biophysics

State Dependent Anionic Pore Currents Conducted by Single Countercharge Mutants in a Voltage-Sensing Phosphatase

R. Shen, E. Perozo, B. Roux

The paper shows that mutating a countercharge residue in a voltage-sensing phosphatase creates anion-selective omega currents through altered electrostatic potential and water pathways.

bioRxiv · Apr 4, 2022 · PreprintBiophysics

Mechanism of Voltage Gating in the Voltage-Sensing Phosphatase Ci-VSP

R. Shen, Y. Meng, B. Roux, E. Perozo

The paper investigates the voltage gating mechanism of Ci-VSP's voltage-sensing domain using simulations and experiments, identifying four states and charge movement during activation.

bioRxiv · Feb 17, 2022Biophysics

Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2

A. Barreiro, A. Prenafeta, G. Bech-Sabat, M. Roca, E. Perozo, R. March, L. Gonzalez-Gonzalez, L. Madrenas, J. Corominas, A. Fernandez, A. Moros, M. Molas, T. Pentinat-Pelegrin, C. Panosa, A. Moreno, , Barr

This paper evaluates a recombinant RBD fusion heterodimer vaccine in mice, showing 100% efficacy against SARS-CoV-2 variants and neutralizing antibodies.

bioRxiv · Nov 22, 2021Immunology