Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions
A. M. Braxton, A. L. Kiemen, M. P. Grahn, A. Forjaz, J. M. Babu, L. Zheng, L. Jiang, H. Cheng, Q. Song, R. Reichel, S. Graham, A. I. Damanakis, C. G. Fischer, S. Mou, C. Metz, , L. D. Wood
This study uses 3D imaging and genomic analysis to show that human pancreatic precancerous lesions (PanINs) are highly multifocal and genetically heterogeneous.
bioRxiv · Jan 27, 2023 · PreprintCancer Biology