L. Jiang

Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections

The paper examines how sequential Omicron infections affect ancestral SARS-CoV-2 immune imprinting, finding that it persists on the RBD but not the NTD.

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

The Microbiome and Metatranscriptome of a Panel from the Sarracenia Mapping Population Reveal Complex Assembly and Function Involving Host Influence.

This study analyzes the microbiome and metatranscriptome of Sarracenia species to reveal host-influenced community structure and functional convergence.

Electrostatic interactions in nucleosome and higher-order structures are regulated by protonation state of histone ionizable residue

The paper investigates how changes in histone protonation states affect nucleosome electrostatic potentials and interactions with partner proteins, and how cancer mutations influence these interactions.

Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages

This study identifies pro-inflammatory macrophages as key regulators of the PE-specific immune microenvironment, linking them to Th17 and CD8+ T cell activation and gMDSC suppression in placental tissues.

Geranylgeranylated-SCFFBXO10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function

This study identifies how geranylgeranylation of FBXO10 enables its targeting to the outer mitochondrial membrane, where it regulates PGAM5 ubiquitination and mitochondrial function.

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

Development of BODIPY-based fluorescent probes for highly selective amino acid identification

This paper develops BODIPY-based fluorescent probes for selective amino acid identification through optimized spectral and photophysical properties.

Selective dissociation of vacant 70S ribosomes by RsfS promotes bacterial adaptation to nutrient starvation

This study shows RsfS selectively dissociates vacant 70S ribosomes during nutrient starvation, improving bacterial survival by conserving energy.

Large-scale multi-omics analyses identified root-microbiome associations underlying plant nitrogen nutrition

The paper identifies root-microbiome associations affecting plant nitrogen nutrition through multi-omics analyses of 1,341 rapeseed samples.

Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease

This study tracks microbiome changes across four body sites in 86 participants over six years, revealing site-specific stability, individualized dynamics, and altered patterns in insulin-resistant individuals.

Inhibition of KLK8 promotes pulmonary endothelial repair by restoring VE-cadherin/Akt/FOXM1 pathway

This study shows that inhibiting KLK8 restores the VE-cadherin/Akt/FOXM1 pathway, promoting endothelial repair and reducing sepsis-induced lung injury and mortality.

Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma

This study evaluates the therapeutic potential of RMC-7977, a broad-spectrum RAS inhibitor, in pancreatic ductal adenocarcinoma models, showing strong anti-tumor effects with minimal impact on normal tissues.

Regulated Cleavage and Relocation of FERONIA Control Immunity in Arabidopsis Roots

Bacteria induce FER cleavage via At2-MMP to trigger localized immunity in Arabidopsis root transition/elongation zones.

Population genetic analyses of longitudinal vaginal microbiome reveal racioethnic evolutionary dynamics and prevailing positive selection of Lactobacillus adhesins

This study analyzes longitudinal vaginal microbiome data from diverse ethnic groups, revealing ethnic signatures in microbial diversity, community states, and evolutionary dynamics, with Lactobacillus adhesins showing positive selection.

An axonemal intron splicing program sustains Plasmodium male development

This study identifies RBPm1 as a splicing activator essential for axoneme assembly in Plasmodium male gametogenesis, revealing an intron splicing program critical for male development.

A redundant chloroplast protein is co-opted by potyvirids as the scaffold protein to mediate viral intercellular movement complex assembly

This study identifies HCPro2 as a potyvirus-encoded scaffold protein that interacts with viral and host factors to assemble an intercellular movement complex, promoting viral infection.

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

This study examines the long-term microbial changes in desert soil during ecological restoration, finding shifts in community structure, functional diversity, and biogeochemical cycles over 17 years.

PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hy-pertension

This study shows PAI-1 deficiency in PASMC promotes pulmonary vascular remodeling and hypertension by enhancing uPA activity, leading to cell proliferation and reduced apoptosis.

Reply to: Contribution of carbon inputs to soil carbon accumulation cannot be neglected

The paper responds to a critique that carbon inputs were neglected in a study on soil carbon storage, arguing that empirical data do not support the critique and that further research is needed.

Rho of plant GTPase MxROP1 regulates Fe deficiency responses by targeting Zinc Ribbon 3 in apple rootstock

This study identifies MxROP1 as a regulator of Fe deficiency responses in apple rootstock by interacting with ZR3.1 and modulating its stability and interaction with MxbHLH39.

PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation

This study shows PSTPIP2 reduces kidney damage in AAN by suppressing IL-19-mediated NET formation and inflammation.

Breakthrough infection elicits hypermutated IGHV3-53/3-66 public antibodies with broad and potent neutralizing activity against SARS-CoV-2 variants including BQ and XBB lineages

This study identifies hypermutated IGHV3-53/3-66 antibodies from breakthrough infections that broadly neutralize SARS-CoV-2 variants including BQ and XBB.

FASN-deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress

This study shows that FASN-deficiency leads to a cytosol-to-mitochondria citrate flux via IDH1 and CTP, which helps cancer cells resist oxidative stress during detachment.

Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics

This paper introduces a single-shot 3D photoacoustic tomography method using a single-element detector to enable ultrafast hemodynamics imaging in humans and small animals.

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.

Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

This study uses 3D imaging and genomic analysis to show that human pancreatic precancerous lesions (PanINs) are highly multifocal and genetically heterogeneous.

Global Transcriptomics of Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease using PCK rats

This study uses RNA-Seq on PCK rat liver samples to identify differentially expressed genes and pathways involved in CHF/ARPKD pathogenesis.

Potent Immunogenicity and Broad-Spectrum Protection Potential of Microneedle Array Patch-Based COVID-19 DNA Vaccine Candidates Encoding Dimeric RBD Chimera of SARS-CoV and SARS-CoV-2 Variants

This study develops DNA vaccines encoding chimeric RBDs of SARS-CoV and SARS-CoV-2 variants, showing potent immunogenicity and broad neutralization against multiple variants.

ABLs and TMKs are co-receptors for extracellular auxin

The paper identifies ABL1 and ABL2 as new auxin receptors that function with TMKs as co-receptors for extracellular auxin, overlapping with but distinct from ABP1.