C. Perry

Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.

The Effect of Adrenalectomy on Bleomycin-Induced Pulmonary Fibrosis in Mice

This study investigates the effect of adrenalectomy on bleomycin-induced pulmonary fibrosis in mice, finding that adrenalectomy reduces lung remodeling but not collagen deposition.

TurboID mapping reveals exportome of secreted intrinsically disordered proteins in the transforming parasite Theileria annulata

This study uses TurboID proximity labeling to identify secreted effector proteins from Theileria annulata, revealing nine nuclear and four cytosolic candidates, eight of which are intrinsically disordered proteins absent in non-transforming species.

Aerosolized α1 adrenoreceptor antagonism does not affect experimentally induced lung fibrosis in animal models

This study tests if inhaled terazosin, an α1 adrenoreceptor antagonist, reduces lung fibrosis in animal models but finds no significant effect.

Deep spatial-omics to aid personalization of precision medicine in metastatic recurrent Head & Neck Cancers

This study uses spatial-omics to identify tumor metabolic states and immune cell profiles in OPSCC, leading to insights on ICI failure and potential drug targets.

The behavioral effects of gestational and lactational benzopyrene exposure vary by sex and genotype in mice with differences at the Ahr and Cyp1a2 loci

This study examines how gestational and lactational exposure to benzo[a]pyrene affects mouse behavior differently by sex and genotype, focusing on the Ahr and Cyp1a2 genes.

The epithelial-mesenchymal transcription factor SNAI1 represses transcription of the tumor suppressor miRNA let-7 in cancer

This study shows SNAI1 represses let-7 miRNA, promoting stemness in cancer cells, and demonstrates nanoparticle-mediated SNAI1 knockdown reduces tumor burden.

Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma

This study characterizes virus-positive and virus-negative Merkel cell carcinomas using deep sequencing, identifying molecular differences and clinical associations with immunosuppression and survival.

Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration ofinflammatory immune cells in EGFR mutant lung tumors

The paper shows that erlotinib and oncogene withdrawal in EGFR mutant lung tumors increase infiltration of inflammatory immune cells, suggesting immunostimulatory effects of tumor regression.