IFNB induced by non-lytic virus immunotherapy promotes improved survival in hepatocellular carcinoma, mediated by MHCII-independent cytotoxic CD4+ T-cells
R. Hughes, A. Moran, K. J. Scott, E. Appleton, M. J. Bentham, E. Ilett, A. Melcher, A. Macdonald, A. Samson, S. Griffin
This paper shows that uv-inactivated reovirus combined with sorafenib improves survival in HCC by promoting IFNβ-induced cytotoxic CD4+ T-cell responses that are MHCII-independent.
bioRxiv · Feb 23, 2024 · PreprintImmunology