Author

A. Samson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Macdonald· 4 shared C. W. Wasson· 2 shared D. Evans· 2 shared E. L. Morgan· 2 shared J. A. Scarth· 2 shared J. Mankouri· 2 shared M. R. Patterson· 2 shared S. Griffin· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersMicrobiology

A. Macdonald

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

IFNB induced by non-lytic virus immunotherapy promotes improved survival in hepatocellular carcinoma, mediated by MHCII-independent cytotoxic CD4+ T-cells

R. Hughes, A. Moran, K. J. Scott, E. Appleton, M. J. Bentham, E. Ilett, A. Melcher, A. Macdonald, A. Samson, S. Griffin

This paper shows that uv-inactivated reovirus combined with sorafenib improves survival in HCC by promoting IFNβ-induced cytotoxic CD4+ T-cell responses that are MHCII-independent.

bioRxiv · Feb 23, 2024 · PreprintImmunology

E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer

M. R. Patterson, A. S. Meijers, E. L. Ryder, J. A. Scarth, D. Evans, A. L. Turner, C. W. Wasson, J. E. Darell, C. D. James, M. Wang, J. E. Ladbury, I. M. Morgan, A. Samson, E. L. Morgan, A. Macdonald

This study shows that HPV E7 represses miR-203, leading to LASP1 upregulation and promoting proliferation in HPV-positive cervical cancer.

bioRxiv · Jan 8, 2024Cancer Biology

Exploitation of ATP-sensitive potassium ion (KATP) channels by HPV promotes cervical cancer cell proliferation by contributing to MAPK/AP-1 signalling

J. A. Scarth, C. W. Wasson, M. R. Patterson, D. Evans, D. Barba-Moreno, H. Carden, A. Whitehouse, J. Mankouri, A. Samson, E. L. Morgan, A. Macdonald

This study shows that HPV exploits KATP channels to promote cervical cancer cell proliferation through MAPK/AP-1 signaling.

bioRxiv · Sep 22, 2022Microbiology

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

J. Shaw, R. Gosein, M. M. Kalita, J. Kankanala, D. R. Mahato, T. Foster, C. Scott, E. Brown, B. J. King, M. Bentham, L. Wetherill, A. Bloy, A. Samson, M. Harris, J. Mankouri, , S. Griffin

The paper designs a rationally derived inhibitor of HCV p7 channel activity, revealing its dual role in virus entry and infection spread, and highlights its potential for bimodal antiviral therapy.

bioRxiv · Oct 7, 2019Microbiology