S. Hahn

HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing of Irgm1

This study identifies hnRNPA2B1 as a splicing regulator that modulates anti-mycobacterial immune responses in macrophages by controlling alternative splicing of Irgm1.

Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation

This study shows CYB5R3 modulates NOX4 activity via coenzyme Q to reduce endothelial inflammation, with in vivo and in vitro evidence of their interaction and functional dependency.

Circulatory neutrophils exhibit enhanced neutrophil extracellular trap formation in early puerperium: NETs at the nexus of thrombosis and immunity?

The paper shows that postpartum neutrophils have increased NET formation, linked to thrombosis and immunity, independent of G-CSF and involving TF, platelets, and microparticles.

Functional metabolic phenotyping of human pancreatic ductal adenocarcinoma

This study identifies functional metabolic differences between PDAC subtypes and shows that non-invasive HP-MRS can detect glycolytic tumor metabolism.

The role of XPB/Ssl2 double-stranded DNA translocase processivity in transcription start-site scanning.

This study compares the dsDNA translocase activity of holo- and core-TFIIH complexes in yeast and humans, finding that human core-TFIIH lacks processive translocation, unlike yeast core-TFIIH which also lacks it but has reduced ATPase activity.

Suv420 enrichment at the centromere limits Aurora B localization and function

This study shows that Suv420 enrichment at centromeres reduces Aurora B localization, leading to mitotic errors and chromosome missegregation, with implications for cancer.

Deep learning enables structured illumination microscopy with low light levels and enhanced speed

This paper uses deep learning to improve structured illumination microscopy, reducing image requirements and enabling low-light, high-speed super-resolution imaging.