Molecular aspects of multivalent engagement between Syk and FcϵRIγ
T. Travers, W. Kanagy, E. Jhamba, B. Goldstein, D. S. Lidke, B. S. Wilson, S. Gnanakaran
The paper models and experimentally validates that cis binding of Syk to FcεRIγ is more effective for signaling than trans binding, with Y130 phosphorylation reducing cis binding.
bioRxiv · Nov 14, 2018 · PreprintBiophysics