Author

D. S. Lidke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Bioengineering· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 3 Assay:imaging· 3 Research Focus:imputation· 3 Assay:fluorescence / live-cell microscopy· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

K. A. Lidke· 4 shared R. M. Grattan· 4 shared B. S. Wilson· 3 shared D. J. Schodt· 2 shared A. Auer· 1 shared A. C. Gibson· 1 shared A. Cambi· 1 shared A. K. N. Shotorban· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersBiophysics

K. A. Lidke

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Author profile →

7 papers

Recent·Most cited

Axial de-scanning using remote focusing in the detection arm of light-sheet microscopy

H. Dibaji, A. K. N. Shotorban, R. M. Grattan, S. Lucero, D. J. Schodt, K. A. Lidke, J. Petruccelli, D. S. Lidke, S. Liu, T. Chakraborty

This paper introduces a novel optical design for axial de-scanning in light-sheet microscopy's detection arm, enabling aberration-free, multi-color volumetric imaging without sample translation.

bioRxiv · Sep 7, 2023Biophysics

Antigen properties shape organization of FcεRI aggregates to tune mast cell signaling

D. A. Rinaldi, W. K. Kanagy, R. M. Grattan, J. C. David, H. C. Kaye, E. A. Burns, S. R. Lucero, M. P. Perez, M. J. Wester, L. Tapia, B. Jacobson, K. A. Lidke, B. S. Wilson, D. S. Lidke

This study shows that antigen properties like valency and epitope spacing shape FcεRI aggregate structure, influencing mast cell signaling outcomes.

bioRxiv · Aug 4, 2023 · PreprintBiophysics

Simultaneous multicolor fluorescence imaging using duplication-based PSF splitting

R. Van den Eynde, F. Hertel, S. Abakumov, B. Krajnik, S. Hugelier, A. Auer, J. Hellmeier, T. Schlichthaerle, R. M. Grattan, D. S. Lidke, R. Jungmann, M. Leutenegger, W. Vandenberg, P. Dedecker

The paper introduces a method to enhance fluorescence imaging by splitting the PSF into multiple copies, enabling simultaneous multicolor imaging with super-resolution and single-molecule capabilities.

bioRxiv · Oct 4, 2022 · PreprintBiophysics

Characterization of the signalling modalities of prostaglandin E2 receptors EP2 and EP4 reveals crosstalk and a role for microtubules

W. Vleeshouwers, K. van den Dries, S. de Keijzer, B. Joosten, D. S. Lidke, A. Cambi

This study characterizes EP2 and EP4 signaling in myeloid cells, revealing cAMP dynamics and microtubule dependence, with EP4 primarily mediating podosome dissolution.

bioRxiv · Oct 6, 2020Immunology

EGFR transactivates RON to drive oncogenic crosstalk

C. Franco Nitta, E. W. Green, E. D. Jhamba, J. M. Keth, I. Ortiz-Caraveo, R. M. Grattan, D. J. Schodt, A. C. Gibson, A. Rajput, K. A. Lidke, M. P. Steinkamp, B. S. Wilson, D. S. Lidke

This study identifies EGFR-dependent phosphorylation of RON and shows direct EGFR-RON interactions drive oncogenic crosstalk, contributing to therapeutic resistance.

bioRxiv · Aug 11, 2020 · PreprintCancer Biology

Molecular aspects of multivalent engagement between Syk and FcϵRIγ

T. Travers, W. Kanagy, E. Jhamba, B. Goldstein, D. S. Lidke, B. S. Wilson, S. Gnanakaran

The paper models and experimentally validates that cis binding of Syk to FcεRIγ is more effective for signaling than trans binding, with Y130 phosphorylation reducing cis binding.

bioRxiv · Nov 14, 2018 · PreprintBiophysics

Sequential Super-Resolution Imaging using DNA Strand Displacement

D. S. Lidke, C. Martin, F. Farzam, J. S. Edwards, S. Pallikkuth, M. R. Lakin, K. A. Lidke

This paper introduces a method for sequential super-resolution imaging using DNA strand displacement to label and remove fluorophores, enabling multiplex imaging of subcellular structures.

bioRxiv · Dec 21, 2017Bioengineering