Glucuronoxylomannan intranasal challenge prior to Cryptococcus neoformans pulmonary infection enhances cerebral cryptococcosis in rodents
H. H. Lee, D. J. Carmichael, V. Ribeiro, D. N. Parisi, M. E. Munzen, M. F. Hamed, E. Kaur, A. Mishra, J. Patel, R. Rooklin, A. Sher, M. A. Carrillo-Sepulveda, E. A. Eugenin, M. R. Dores, L. R. Martinez
This study shows that intranasal GXM administration before C. neoformans infection increases fungal burden in lungs and enhances brain invasion by disrupting the blood-brain barrier.
bioRxiv · Oct 24, 2022 · PreprintMicrobiology