J. Patel

Multi-Model Machine Learning for Automated Identification of Rice Diseases Using Leaf Image Data

This paper develops a hybrid deep-machine learning system for automated rice disease detection using leaf images, achieving high accuracy and efficiency.

MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and Metastasis

This study identifies MICAL2 as a super enhancer-associated gene that promotes pancreatic cancer growth and metastasis through multiple molecular mechanisms.

Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension

This paper develops a two-hit mouse model of HFpEF combining diet-induced obesity and renin-mediated hypertension, showing key features of the disease and response to therapy.

Identification of Fasnall as a therapeutically effective Complex I inhibitor

This study identifies Fasnall as a Complex I inhibitor that mimics FASN inhibition, showing anti-tumor effects without neurological side effects.

Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice

This study shows that SGLT2 inhibitors improve heart failure in mice independently of their metabolic effects, even when SGLT2 is absent.

APOBEC3 mutagenesis drives therapy resistance in breast cancer

This study identifies APOBEC3 mutagenesis as a common driver of therapy resistance in breast cancer, associated with poorer clinical outcomes.

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

This study shows that BT2, an inhibitor of BCKDK, reduces plasma tryptophan by displacing it from albumin, revealing an off-target effect on tryptophan metabolism.

SbPIP2 Mediated Improvements in Plant Resilience: Physiological and Molecular Insights into Abiotic Stress Response

This study shows that overexpressing SbPIP2 improves plant resilience to abiotic stress by reducing ROS, enhancing growth, and modulating ABA signaling pathways.

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

This paper creates a spatial cell atlas of neuroblastoma, revealing tumor heterogeneity through multi-omics data and identifying spatial compartmentalization and signaling patterns.

Structural and functional vascular dysfunction within brain metastases is linked to pembrolizumab inefficacy

This study links structural and functional vascular dysfunction in brain metastases to pembrolizumab resistance by analyzing perfusion MRI data from 44 patients.

Bimodal distribution of Candida albicans in children with Autism linked with ASD symptoms

The paper examines gut mycobiota in children with ASD and TD, finding a bimodal distribution of Candida albicans linked to autism severity and GI symptoms.

Network analysis for identifying potential anti-virulence targets through whole transcriptome analysis of Pseudomonas aeruginosa and Staphylococcus aureus exposed to certain anti-pathogenic polyherbal formulations

Ehrlichia Wnt short linear motif ligand mimetic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis

This study shows Ehrlichia chaffeensis uses a Wnt-like SLiM to deactivate Hippo signaling, activating Yap and the anti-apoptotic Yap-GLUT1-BCL-xL axis, enhancing infection.

Antibody landscape of C57BL/6 mice cured of B78 melanoma via immunotherapy

The paper identifies antibodies targeting melanoma peptides in C57BL/6 mice cured of B78 melanoma via immunotherapy, using proteome arrays and ELISA validation.

Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis

This study shows Ehrlichia chaffeensis uses Notch signaling to stabilize XIAP and inhibit apoptosis, enhancing its survival within host cells.

The Lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding

This study shows that the Lamin A/C Ig-fold undergoes cell density-dependent conformational changes that affect antibody binding, without altering protein levels or nuclear mechanics.

Glucuronoxylomannan intranasal challenge prior to Cryptococcus neoformans pulmonary infection enhances cerebral cryptococcosis in rodents

This study shows that intranasal GXM administration before C. neoformans infection increases fungal burden in lungs and enhances brain invasion by disrupting the blood-brain barrier.

Long-term NAD+ supplementation prevents the progression of age-related hearing loss in mice

This study shows that long-term NR supplementation prevents age-related hearing loss in mice by restoring NAD+ levels and modulating synaptic and lipid pathways.

Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant Mycobacterium tuberculosis

This paper develops amidase-dependent pyrazinoic acid prodrugs that bypass PncA activation, showing efficacy against PZA-resistant Mtb.

Establishing Novel Doxorubicin-Loaded Polysaccharide Hydrogel for Controlled Drug Delivery for Treatment of Pediatric Brain Tumors

This paper develops a doxorubicin-loaded polysaccharide hydrogel for targeted drug delivery in pediatric brain tumors, showing sustained drug release and cytotoxicity against medulloblastoma cells.

Apurinic/apyrimidinic nuclease 1 drives genomic evolution contributing to chemoresistance and tumorigenesis in solid tumor

This study identifies APE1 as a driver of genomic instability in solid tumors, showing its role in chemoresistance and tumorigenesis through effects on DNA repair and genome stability.

Hand Gesture Prediction via Transient-phase sEMG using Transfer Learning of Dilated Efficient CapsNet: Towards Generalization for Neurorobotics

This paper proposes a dilated efficient capsular neural network with transfer learning for hand gesture prediction using sEMG signals, showing improved performance with limited individual data.

TP53 knockout in MCF7 breast cancer cells induces sensitivity to fluoropyrimidine drugs.

This study shows TP53 knockout in breast cancer cells increases sensitivity to fluoropyrimidine drugs like F10, with DNA incorporation as a key mechanism.

Ehrlichia SLiM ligand mimetic activates Notch signaling in human monocytes

This paper identifies a short linear motif (SLiM) in the Ehrlichia TRP120 effector that mimics Notch ligands to activate Notch signaling in human monocytes.

Communicating Regulatory High Throughput Sequencing Data Using BioCompute Objects

The paper demonstrates that BioCompute Objects (BCOs) enable high concordance (99.15%) in replicating NGS analysis results across simulated regulatory submissions and reviews.

HSP90 facilitates oncogenic alterations of metabolism in B-cell lymphomas

This study shows HSP90 supports metabolic compartmentalization in B-cell lymphomas, and its inhibition reduces cancer metabolism.

Recapitulation of human embryonic heart beating to promote differentiation of hepatic endoderm to hepatoblasts

The paper uses a microfluidic platform to simulate human heart beats, enhancing the functional properties of hepatoblasts derived from hepatic endoderm.

Deceptive combined effects of short allele dominance and stuttering: an example with Ixodes scapularis, the main vector of Lyme disease in the U.S.A.

The paper examines how short allele dominance and stuttering in microsatellite data affect genetic diversity metrics in Ixodes scapularis ticks, showing significant heterozygote deficits and linkage disequilibrium.

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

This study shows that LMNA mutations cause nuclear envelope rupture and DNA damage in muscle cells, leading to disease through mechanical stress and DNA damage pathways.

High-throughput identification of MHC class I binding peptides using an ultradense peptide array

This paper uses an ultradense peptide array to identify MHC class I binding peptides, finding 64% of known epitopes and three novel ones in rhesus macaques.