Author

E. Kelleher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4

Signature Assays, Organisms & Methods

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Organism:Drosophila· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

L. Wang· 2 shared S. Zhang· 2 shared D. Barbash· 1 shared E. SIlva· 1 shared L. Nguyen· 1 shared L. Saiz· 1 shared S. Hadjipanteli· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersEvolutionary Biology

L. Wang

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4 papers

Recent·Most cited

TE invasion fuels molecular adaptation in laboratory populations of Drosophila melanogaster

S. Zhang, L. Wang, S. Hadjipanteli, L. Saiz, L. Nguyen, E. SIlva, E. Kelleher

This study shows that transposable element invasion in Drosophila melanogaster leads to molecular adaptation through recurrent insertions into a specific lncRNA under positive selection.

bioRxiv · Jun 6, 2022 · PreprintEvolutionary Biology

Protein-Protein Interactions Shape Genomic Autoimmunity in the Adaptively-Evolving Rhino-Deadlock-Cutoff (RDC) Complex

E. Kelleher

The paper examines autoimmunity in the piRNA pathway by analyzing protein-protein interactions in Drosophila species.

Genome Biology and Evolution · Jul 6, 2021Peer-reviewedEvolutionary Biology

Adaptive evolution among cytoplasmic piRNA proteins leads to decreased genomic auto-immunity

L. Wang, D. Barbash, E. Kelleher

This study investigates adaptive evolution of piRNA pathway proteins in Drosophila and finds that their evolution is driven by avoiding genomic auto-immunity rather than enhancing TE silencing.

PLOS Genetics · Jun 11, 2020Peer-reviewedEvolutionary Biology

piRNA-mediated silencing of an invading transposable element evolves rapidly through abundant de novo mutations

S. Zhang, E. Kelleher

The paper shows that piRNA-mediated repression of P-elements in Drosophila evolves rapidly through frequent de novo mutations, not adaptive selection.

bioRxiv · Jan 28, 2020Evolutionary Biology