Modulation of the tumour promoting functions of cancer associated fibroblasts by phosphodiesterase type 5 inhibition increases the efficacy of chemotherapy in human preclinical models of esophageal adenocarcinoma.
A. Hayden, A. Manousopoulou, A. Cowie, R. Walker, B. P. Sharpe, J. Harrington, F. Izadi, E. Kyle, J. H. Saunders, S. L. Parsons, A. A. Ritchie, P. A. Clarke, P. Collier, S. D. Garbis, M. Rose-Zerilli, , T. J. Underwood
This study shows that PDE5 inhibition reduces CAF tumor-promoting effects and enhances chemotherapy efficacy in EAC models.
bioRxiv · Apr 21, 2020 · PreprintCancer Biology