A. Hayden

High-throughput single-molecule quantification of individual base stacking energies in nucleic acids

This study measures individual base stacking energies in DNA and RNA using a custom Centrifuge Force Microscope, finding stronger stacking between purines and weaker between pyrimidines, with implications for DNA nanostructures, enzymatic ligation, and MD simulations.

Modulation of the tumour promoting functions of cancer associated fibroblasts by phosphodiesterase type 5 inhibition increases the efficacy of chemotherapy in human preclinical models of esophageal adenocarcinoma.

This study shows that PDE5 inhibition reduces CAF tumor-promoting effects and enhances chemotherapy efficacy in EAC models.