Cancer BiologybioRxivPreprint
Modulation of the tumour promoting functions of cancer associated fibroblasts by phosphodiesterase type 5 inhibition increases the efficacy of chemotherapy in human preclinical models of esophageal adenocarcinoma.
A. Hayden, A. Manousopoulou, A. Cowie…·T. J. Underwood
This study shows that PDE5 inhibition reduces CAF tumor-promoting effects and enhances chemotherapy efficacy in EAC models.
DOI 10.1101/2020.04.21.052647