STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cells
L. Richart Gines, E. Lapi, V. Pancaldi, M. Cuenca, E. Castillo de Santa Pau, M. Madrid, H. Neyret-Kahn, F. Radvanyi, J. Rodriguez, Y. Cuartero, F. Serra, F. Le Dily, A. Valencia, M. A. Marti-Renom, F. X. Real
This study investigates how STAG2 loss-of-function affects genomic contacts and urothelial differentiation in bladder cancer cells, finding that STAG2 is critical for DNA looping that sustains luminal differentiation.
bioRxiv · Aug 6, 2020 · PreprintCancer Biology