J. Rodriguez

Stepwise neofunctionalization of the NF-κB family member c-Rel during vertebrate evolution

The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.

Prioritizing Maize Metabolic Gene Regulators through Multi-Omic Network Integration

This paper develops a framework to prioritize maize metabolic gene regulators by integrating multi-omic data, identifying over 3,000 TFs and predicting new regulators of hormone, developmental, and metabolic processes.

Multi-Omics Analysis Of Antiviral Interactions Of Elizabethkingia anophelis And Zika Virus

This study investigates the antiviral interactions between Elizabethkingia anophelis and Zika virus using multi-omics analysis, revealing attenuated viral replication and altered metabolic pathways.

Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment

The paper uses correlative single molecule lattice light sheet imaging to study nucleosome dynamics and chromatin environment interactions in live cells, revealing differential diffusion and packing with increasing chromatin density.

Atypical Protein Kinase C Promotes its own Asymmetric Localisation by Phosphorylating Cdc42 in Polarising Cells

This paper shows that aPKC phosphorylates Cdc42 to regulate its own asymmetric localization and cell polarity in C. elegans zygotes.

ERα mediated gene state switching regulates the extent of the single-cell estrogen response

The paper investigates how altered ERα function and cofactor recruitment affect transcriptional bursting in estrogen responsive genes, finding gene-specific reductions in active alleles in BPA-treated cells.

Histopathology-assisted proteogenomics provides foundations for stratification of melanoma metastases

This study integrates histopathology and proteogenomic data from melanoma metastases to identify subtypes and risk factors, offering a basis for personalized treatment strategies.

MiDAS 5: Global diversity of bacteria and archaea in anaerobic digesters

The paper expands the MiDAS database with global anaerobic digester microbiome data, revealing environmental influences on microbial communities and identifying core taxa.

Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons

This paper uses machine learning to design cytotoxic T cell epitopes by modeling proteasomal degradation scores and testing their immunogenicity.

An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3 stability.

A high-throughput compound screen identified JG98 and parthenolide as reducing MyBP-C levels, revealing the Hsp70-BAG3 complex as a regulator of MyBP-C stability in HCM.

Targeting caveolae to pump bispecific antibody to TGF-β into diseased lungs enables ultra-low dose therapeutic efficacy

This paper develops a bispecific antibody that targets caveolae to deliver TGF-β inhibitors specifically to lungs, achieving ultra-low dose therapeutic efficacy in a rat model.

Isolation of a potently neutralizing and protective human monoclonal antibody targeting yellow fever virus

The paper isolates a human monoclonal antibody that neutralizes yellow fever virus and provides therapeutic protection in animal models.

Reduced platelet forces underlie impaired hemostasis in mouse models of MYH9-related disease

This study shows that reduced platelet forces in Myh9 mutant mice cause impaired hemostasis, which can be improved by tranexamic acid.

Ribosome elongation kinetics of consecutively charged residues are coupled to electrostatic force

The paper shows charged residues affect ribosome elongation speed through mechanochemical forces, supported by simulations and experimental data.

Locally secreted BiTEs complement CAR T cells by enhancing solid tumor killing

This study shows that BiTE-secreting T cells outperform CAR T cells in killing glioma cells in vitro and in vivo, with enhanced cytotoxicity and tumor growth delay.

Effect of temperature and loading frequency on the performance of vertical subsurface flow constructed wetlands: Modelling study using HYDRUS

This study uses HYDRUS-2D to model how temperature and loading frequency affect vertical subsurface flow constructed wetlands' performance, finding oxygen limitation at high temperatures and improved performance with higher loading frequencies.

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

This paper determines the structures of two antibodies in the AZD7442 cocktail that neutralize SARS-CoV-2 and identifies critical residues for neutralization and viral escape.

STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cells

This study investigates how STAG2 loss-of-function affects genomic contacts and urothelial differentiation in bladder cancer cells, finding that STAG2 is critical for DNA looping that sustains luminal differentiation.

A novel role of MNT as a negative regulator of REL and the NF-κB pathway

This study identifies MNT as a negative regulator of the NF-κB pathway by inhibiting REL translocation and repressing REL-target genes through a MNT-REL complex.

Effectiveness of Growth Hormone Releasing Hormone Agonists (GHRH A) in Chronic Kidney Disease Induced Heart Failure with Preserved Ejection Fraction

This study tests GHRH-A treatment in a CKD-induced HFpEF pig model, finding improved diastolic function after 6 weeks of treatment.

Karyotype asymmetry shapes diversity within the physaloids (Physalidinae, Physalideae, Solanaceae)

The paper uses cytogenetic analyses and phylogenetic methods to show that karyotype asymmetry contributes to diversification in Physalidinae, aiding in genus differentiation.

Asparagine hydroxylation is likely to be a reversible post-translational modification

The paper shows that asparagine hydroxylation can be reversed by cellular machinery, challenging the view that it is irreversible.

Optimal microbial pathway variants can be determined by large-scale bioenergetic evaluation in syntrophic propionate oxidation

This study evaluates optimal microbial pathway variants for propionate oxidation under various conditions, finding that lactate-based pathways yield the most ATP and suggesting non-hydrogen IET mechanisms are necessary.

Cdc42EP5/BORG3 modulates SEPT9 to promote actomyosin function and melanoma invasion and metastasis

This study shows Cdc42EP5 regulates melanoma invasion and metastasis by modulating SEPT9 to enhance actomyosin contractility and F-actin crosslinking.

Parallel Concerted Evolution of Ribosomal Protein Genes in Fungi and Its Adaptive Significance

This study investigates the duplication and maintenance of ribosomal protein genes in fungi, finding parallel concerted evolution and adaptive advantages in sugar-rich environments.

ASSEMBLY MECHANISMS OF NEOTROPICAL BUTTERFLY COMMUNITIES ALONG AN ENVIRONMENTAL GRADIENT

This study tests the hypothesis that competition drives community assembly in stable environments while habitat filtering dominates in variable ones, finding the opposite pattern in Neotropical butterfly communities.

Rainfall As A Significant Contributing Factor To Butterfly Seasonality Along A Climatic Gradient In The Neotropics

This study examines how rainfall influences butterfly seasonality across different climatic zones in the Neotropics over three years.

PI31 is an adaptor protein for proteasome transport in axons and required for synaptic development and function

This study identifies PI31 as an adaptor protein linking proteasomes to dynein motors in axons, showing its role in synaptic development and function through regulated transport.

Pollinator size and its consequences: Predictive allometry for pollinating insects

This study develops predictive allometric models for pollinator body size using Bayesian and OLS regression, showing better interspecific than intraspecific predictions.

Analysis of global and site-specific radiation damage in cryo-EM

The paper analyzes radiation damage in cryo-EM using MicroED, finding similar damage dynamics to X-ray crystallography, including metal ion perturbation and disulfide bond breaking.