V. Pancaldi

Global chromatin reorganization and regulation of genes with specific evolutionary ages during differentiation and cancer

The paper investigates how chromatin organization and gene regulation change with evolutionary age during differentiation and cancer, identifying shifts in chromatin topology and gene interactions.

Cytidine deaminase protects pancreatic cancer cells from replicative stress and drives resistance to DNA-targeting drugs

This study shows that Cytidine deaminase (CDA) protects pancreatic cancer cells from replication stress and contributes to resistance against DNA-targeting drugs.

Low replication stress leads to specific replication timing advances associated to chromatin remodelling in cancer cells

The paper examines how low replication stress affects replication timing in cancer cells, revealing chromatin remodelling and inheritance of timing advances.

STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cells

This study investigates how STAG2 loss-of-function affects genomic contacts and urothelial differentiation in bladder cancer cells, finding that STAG2 is critical for DNA looping that sustains luminal differentiation.

The antitumoral activity of TLR7 ligands is corrupted by the microenvironment of pancreatic tumors

This study shows that TLR7 ligands inhibit pancreatic cancer cell growth in vitro but promote tumor growth in immunocompetent mice due to increased tumor-promoting macrophages.