The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans
O. Al Rifai, C. Julien, D. Faubert, E. Lira-Navarrete, Y. Narimatsu, J. Lacombe, H. Clausen, M. Ferron
The study shows that O-glycosylation extends the half-life of mouse osteocalcin but not human osteocalcin, highlighting a species difference in hormone regulation.
bioRxiv · Jul 16, 2020Biochemistry