Author

J. Lacombe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. Faubert· 3 shared M. Ferron· 3 shared A. Germain· 1 shared A. Vivoli· 1 shared C. Julien· 1 shared C. Schott· 1 shared E. Lira-Navarrete· 1 shared F. Gioanni· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersPhysiology

D. Faubert

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Author profile →

3 papers

Recent·Most cited

GAS6 and AXL promote insulin resistance by rewiring insulin signaling and increasing insulin receptor trafficking to endosomes

C. Schott, A. Germain, J. Lacombe, M. Pata, D. Faubert, J. Boulais, J.-F. Cote, M. Ferron

This study shows GAS6 and AXL reduce insulin sensitivity by altering insulin signaling and increasing insulin receptor trafficking to endosomes.

bioRxiv · Oct 19, 2023Physiology

Vitamin K-dependent carboxylation regulates calcium flux and adaptation to metabolic stress in β-cells

J. Lacombe, K. Guo, J. Bonneau, D. Faubert, F. Gioanni, A. Vivoli, S. M. Muir, S. Hezzaz, V. Poitout, M. Ferron

This study shows that vitamin K-dependent gamma-carboxylation in beta-cells regulates calcium flux and adaptation to metabolic stress by modulating ERGP function.

bioRxiv · May 13, 2022 · PreprintCell Biology

The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

O. Al Rifai, C. Julien, D. Faubert, E. Lira-Navarrete, Y. Narimatsu, J. Lacombe, H. Clausen, M. Ferron

The study shows that O-glycosylation extends the half-life of mouse osteocalcin but not human osteocalcin, highlighting a species difference in hormone regulation.

bioRxiv · Jul 16, 2020Biochemistry