M. Ferron

GAS6 and AXL promote insulin resistance by rewiring insulin signaling and increasing insulin receptor trafficking to endosomes

This study shows GAS6 and AXL reduce insulin sensitivity by altering insulin signaling and increasing insulin receptor trafficking to endosomes.

Vitamin K-dependent carboxylation regulates calcium flux and adaptation to metabolic stress in β-cells

This study shows that vitamin K-dependent gamma-carboxylation in beta-cells regulates calcium flux and adaptation to metabolic stress by modulating ERGP function.

In vivo analysis of the contribution of proprotein convertases to the processing of FGF23

This study investigates the role of proprotein convertases in FGF23 processing in vivo, finding that furin contributes to cleavage under specific conditions but not universally.

The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

The study shows that O-glycosylation extends the half-life of mouse osteocalcin but not human osteocalcin, highlighting a species difference in hormone regulation.

PHOSPHO1, a novel skeletal regulator of insulin resistance and obesity

This study shows that PHOSPHO1 deficiency improves glucose homeostasis and protects against obesity and diabetes without altering osteocalcin levels.