BiophysicsbioRxiv
Preferential phosphatidylinositol 5-phosphate binding contributes to a destabilization of the VHS domain structure of Tom1
W. Xiong, T.-X. Tang, E. Littleton…·D. G. S. Capelluto
This study shows that PtdIns5P binding destabilizes the Tom1 VHS domain structure, affecting its function and contributing to bacterial survival during Shigella infection.
DOI 10.1038/s41598-019-47386-z