W. Xiong

This study identifies Tad1 and Tad2 as phage proteins that sequester cyclic nucleotides produced by TIR and cGAS systems to inhibit anti-phage immunity.

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

This study identifies LPHN2 as a force-sensing GPCR critical for auditory function, showing its role in mechanoelectrical transduction and hearing loss when deficient.

This study identifies an IKK/β-TrCP2 phosphorylation-ubiquitination cascade that regulates TFEB stability, independent of other regulators.

This study shows that PKA catalytic subunits dissociate from regulatory subunits in neurons upon activation, which is necessary for synaptic plasticity and transmission.

This study presents a high-quality genome assembly of Lactuca virosa and analyzes its genetic variation compared to related species, identifying genomic features that may impact lettuce breeding.

This study presents the genome of Gynandropsis gynandra, revealing whole-genome duplications and gene retention patterns related to C4 photosynthesis evolution in Cleomaceae.

The paper proposes updated nomenclature for plant ribosomal protein genes to improve adoption in plant biology, extending previous systems to include organellar ribosomes and additional species.

This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.

This study shows that homogeneous antibody-drug conjugates (ADCs) improve therapeutic efficacy in glioblastoma models compared to heterogeneous ADCs.

The paper demonstrates active anaerobic methane oxidation and sulfur disproportionation in deep terrestrial subsurface environments using metaproteogenomics and isotopic analysis.

This study develops dual-payload antibody-drug conjugates to overcome breast tumor heterogeneity and drug resistance, showing improved efficacy in a xenograft model.

This study introduces terahertz wave modulation to enhance hearing perception in animals by increasing cochlear hair cell currents and sensitivity without genetic modification.

This paper develops an in vitro assay to evaluate nucleotide analogs against SARS-CoV-2 RdRp, showing varying incorporation efficiencies and chain termination effects.

This study evaluates isopropoxy benzene guanidine's antimicrobial activity against S. aureus, showing potent activity and low resistance potential.

This study shows that PtdIns5P binding destabilizes the Tom1 VHS domain structure, affecting its function and contributing to bacterial survival during Shigella infection.

This study identifies TMC1 as providing a background leak conductance in mouse auditory hair cells, essential for action potential firing and tonotopic organization.

This study examines microbial colonization in premature infants, finding distinct proteomic profiles among related bacterial strains and correlations with NEC development.