Author

I. M. Lazar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Karcini· 3 shared S. Ahuja· 2 shared D. G. S. Capelluto· 1 shared E. Littleton· 1 shared J. R. Haueis· 1 shared T.-X. Tang· 1 shared W. Xiong· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

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3 shared papersCancer Biology

A. Karcini

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Proteomic Insights into Breast Cancer Response to Brain Cell-Secreted Factors

S. Ahuja, I. M. Lazar

This study investigates how HER2+ breast cancer cells respond to brain cell-secreted factors, finding that exposure leads to quiescence and altered cellular processes.

bioRxiv · Oct 22, 2023 · PreprintCancer Biology

Mapping the Cell-Membrane Proteome to the Cancer Hallmarks

I. M. Lazar, A. Karcini, J. R. Haueis

This paper maps cell-membrane proteins to cancer hallmarks to identify novel therapeutic targets and network hubs.

bioRxiv · Mar 18, 2022 · PreprintCancer Biology

The SKBR3 Cell-Membrane Proteome: Role in Aberrant Cancer Cell Proliferation and Resource for Precision Medicine Applications

A. Karcini, I. M. Lazar

This study characterizes the SKBR3 cell-membrane proteome, identifying numerous tumor markers and drug targets, and reveals its role in cancer proliferation and therapeutic resistance.

bioRxiv · Oct 24, 2021 · PreprintCancer Biology

Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-inflammatory Cytokines

S. Ahuja, I. M. Lazar

The paper uses proteomics to analyze how microglia respond to anti-inflammatory cytokines, identifying tumor-promoting processes and signaling pathways involved.

bioRxiv · Feb 4, 2021Immunology

Preferential phosphatidylinositol 5-phosphate binding contributes to a destabilization of the VHS domain structure of Tom1

W. Xiong, T.-X. Tang, E. Littleton, A. Karcini, I. M. Lazar, D. G. S. Capelluto

This study shows that PtdIns5P binding destabilizes the Tom1 VHS domain structure, affecting its function and contributing to bacterial survival during Shigella infection.

bioRxiv · Jun 14, 2019Biophysics