Author

E. M. Garcia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. P. Dillard· 2 shared N. Z. Lue· 2 shared A. K. Klimowicz· 1 shared B. B. Liau· 1 shared B. Liau· 1 shared C. Lee· 1 shared C. S. Pepperell· 1 shared D. D. Hwang· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

J. P. Dillard

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Base Editor Scanning Reveals Activating Mutations of DNMT3A

E. M. Garcia, N. Z. Lue, J. K. Liang, W. K. Lieberman, D. D. Hwang, J. Woods, B. Liau

The paper uses base editor mutagenesis to identify activating DNMT3A mutations, revealing hyperactivating variants in the ADD domain that remain functional in the presence of a heterozygous R882H mutation.

bioRxiv · Apr 12, 2023Biochemistry

Genotypic and phenotypic differences among phase-variable colony variants conserved across Gardnerella spp.

E. M. Garcia, A. K. Klimowicz, L. Edupuganti, M. A. Topf, S. R. Bhide, D. J. Slusser, S. M. Leib, G. A. Buck, K. K. Jefferson, C. S. Pepperell, J. P. Dillard

This study identifies phase-variable colony variants in Gardnerella species and their potential roles in bacterial vaginosis pathogenesis.

bioRxiv · Jan 13, 2023 · PreprintMicrobiology

IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube

E. M. Garcia, J. D. Lenz, K. T. Hackett, W. Salgado-Pabon, J. P. Dillard

This study identifies IL-17C as a key driver of inflammation and tissue damage in human Fallopian tubes during Neisseria gonorrhoeae infection.

bioRxiv · Nov 28, 2022 · PreprintMicrobiology

Base editor scanning charts the DNMT3A activity landscape

N. Z. Lue, E. M. Garcia, K. C. Ngan, C. Lee, J. G. Doench, B. B. Liau

The paper uses base editing and a DNA methylation reporter to scan DNMT3A mutations, identifying functional perturbations and revealing a noncanonical DNA affinity role for the PWWP domain.

bioRxiv · Apr 12, 2022Biochemistry