Differential requirement for IRGM proteins during tuberculosis infection in mice
K. M. Wilburn, R. K. Meade, E. M. Heckenberg, J. Dockterman, J. Coers, C. M. Sassetti, A. J. Olive, C. M. Smith
This study shows that Irgm1 is critical for host defense against Mtb, but Irgm3 compensates for its loss, and combined loss of all three Irgm genes leads to worse outcomes in mice infected with Mtb.
bioRxiv · Nov 9, 2022Microbiology