A. J. Olive

GSK3α/β restrains IFNγ-inducible costimulatory molecule expression in alveolar macrophages, limiting CD4+ T cell activation

Immunometabolic cues recompose and reprogram the microenvironment around biomaterials

The paper shows that immunometabolic cues around biomaterials influence immune cell trafficking and microenvironment composition, promoting a pro-regenerative state through metabolic reprogramming.

Rapid lethality of mice lacking the phagocyte oxidase and Caspase1/11 following Mycobacterium tuberculosis infection.

This study shows that mice lacking both phagocyte oxidase and Caspase1/11 die rapidly from tuberculosis due to severe inflammation and bacterial growth.

A genome-wide screen in macrophages defines host genes regulating the uptake of Mycobacterium abscessus.

This study identifies host genes regulating Mycobacterium abscessus uptake by macrophages using a genome-wide knockout screen in murine macrophages, revealing a key role for glycosaminoglycan synthesis.

A genome-wide screen in macrophages identifies PTEN as required for myeloid restriction of Listeria monocytogenes infection

This study identifies PTEN as a host factor required for macrophage phagocytosis of Listeria monocytogenes, revealing its role in bacterial adherence and host protection during infection.

Differential requirement for IRGM proteins during tuberculosis infection in mice

This study shows that Irgm1 is critical for host defense against Mtb, but Irgm3 compensates for its loss, and combined loss of all three Irgm genes leads to worse outcomes in mice infected with Mtb.

Mitochondrial respiration contributes to the interferon gamma response in antigen presenting cells

This study identifies mitochondrial respiration as essential for the interferon gamma response in antigen presenting cells, showing that complex I inhibition blocks T cell activation.

Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase

This study shows that Mycobacterium tuberculosis relies on cytochrome bd oxidase to resist the adaptive immune response, particularly under acidic conditions in macrophages.

Mycobacterium tuberculosis evasion of Guanylate Binding Protein-mediated host defense in mice requires the ESX1 secretion system.

This study shows that Mycobacterium tuberculosis evades GBP-mediated immunity in mice via the ESX1 secretion system, unlike M. bovis BCG which is directly restricted by GBPs.

The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis infection.

This study shows that the Phox complex promotes tolerance to Mycobacterium tuberculosis infection by preventing uncontrolled Caspase1 activation and neutrophil influx.