Author

J. Coers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 10 Organism:mouse· 7 Research Focus:cell type annotation· 5 Organism:human· 5 Assay:proteomics· 4 Approach:genetic perturbation / CRISPR· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

G. Wallace· 3 shared J. Dockterman· 3 shared M. Kutsch· 3 shared A. J. Olive· 2 shared A. Piro· 2 shared c. lesser· 2 shared C. M. Sassetti· 2 shared C. M. Smith· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

G. Wallace

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11 papers

Recent·Most cited

An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity

S. Kirchner, V. Lei, P. Kim, M. Patel, J. Shannon, D. Corcoran, D. Hughes, D. Waters, K. Dzirasa, D. Erdmann, J. Coers, A. MacLeod, J. Zhang

This study identifies a circadian rhythm that regulates antiviral immunity in skin, showing that aging disrupts this rhythm and that circadian enhancers can restore antiviral defenses.

bioRxiv · Apr 14, 2023 · PreprintImmunology

GBP2 aggregates LPS and activates the caspase-4 inflammasome independent of the bacterial encapsulation factor GBP1

M. S. Dickinson, M. Kutsch, L. Sistemich, D. Hernandez, D. Needham, c. lesser, C. Herrmann, J. Coers

This paper shows GBP2 can trigger pyroptosis by aggregating free LPS and activating caspase-4, independent of GBP1's bacterial binding function.

Proceedings of the National Academy of Sciences · Apr 6, 2023Peer-reviewedImmunology

The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation

R. J. Bastidas, M. Kedzior, R. K. Davidson, S. C. Walsh, L. Dolat, B. S. Sixt, J. N. Pruneda, J. Coers, R. H. Valdivia

The study shows that Cdu1's acetylase activity protects Chlamydia effectors from degradation, enabling bacterial exit from host cells.

bioRxiv · Feb 28, 2023Microbiology

Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation

L. Goers, K. Kim, P. J. Canning, T. C. Stedman, X. Mou, N. Heinz Ernst, J. Coers, c. F. lesser

This study shows that Shigella IpaH9.8 inhibits GBP1-dependent LPS release from intracellular bacteria, preventing caspase-4 activation and pyroptosis.

bioRxiv · Nov 14, 2022 · PreprintMicrobiology

Differential requirement for IRGM proteins during tuberculosis infection in mice

K. M. Wilburn, R. K. Meade, E. M. Heckenberg, J. Dockterman, J. Coers, C. M. Sassetti, A. J. Olive, C. M. Smith

This study shows that Irgm1 is critical for host defense against Mtb, but Irgm3 compensates for its loss, and combined loss of all three Irgm genes leads to worse outcomes in mice infected with Mtb.

bioRxiv · Nov 9, 2022Microbiology

Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection

J. Dockterman, J. I. Everitt, G. Wallace, J. Coers

This paper shows that Irgm proteins in mice reduce inflammation and scarring during Chlamydia infection without affecting bacterial levels, highlighting their role in disease tolerance.

bioRxiv · Jul 6, 2022 · PreprintImmunology

Mycobacterium tuberculosis evasion of Guanylate Binding Protein-mediated host defense in mice requires the ESX1 secretion system.

A. J. Olive, C. M. Smith, C. E. Baer, J. Coers, C. M. Sassetti

This study shows that Mycobacterium tuberculosis evades GBP-mediated immunity in mice via the ESX1 secretion system, unlike M. bovis BCG which is directly restricted by GBPs.

bioRxiv · Jul 27, 2020Microbiology

Dynamin-related Irgm proteins modulate LPS-induced caspase-4 activation and septic shock

R. Finethy, J. Dockterman, M. Kutsch, N. Orench-Rivera, G. Wallace, A. Piro, S. Luoma, A. Haldar, S. Hwang, J. Martinez, M. Kuehn, G. Taylor, J. Coers

This study identifies Irgm proteins as negative regulators of caspase-4 activation in response to LPS, showing their role in preventing septic shock.

bioRxiv · Mar 18, 2020Immunology

IRG1 and iNOS act redundantly with other interferon gamma induced factors to restrict intracellular replication of Legionella pneumophila.

J. V. Price, D. Russo, D. X. Ji, R. A. Chavez, L. DiPeso, A. Y.-F. Lee, J. Coers, R. Vance

The paper identifies six IFN-gamma-induced genes, including IRG1 and iNOS, that redundantly restrict L. pneumophila replication in macrophages.

bioRxiv · Aug 10, 2019Immunology

A rapidly evolving polybasic motif modulates bacterial detection by guanylate binding proteins

K. M. Kohler, M. Kutsch, A. S. Piro, G. Wallace, J. Coers, M. F. Barber

The paper shows that a rapidly evolving polybasic motif in primate GBP proteins modulates bacterial detection, specifically targeting Shigella flexneri through evolutionary changes.

bioRxiv · Jul 2, 2019Microbiology

Detection of cytosolic Shigella flexneri via a C-terminal triple-arginine motif of GBP1 inhibits actin-based motility

A. Piro, D. Hernandez, S. Luoma, E. Feeley, R. Finethy, A. Yirga, E. Frickel, C. Lesser, J. Coers

This paper shows human GBP1 uniquely captures cytosolic Gram-negative bacteria via a C-terminal triple-arginine motif, inhibiting their actin-based motility and cell-to-cell spread, while Shigella uses IpaH9.8 to resist GBP1 targeting.

bioRxiv · Nov 1, 2017Microbiology