Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins
F. Zhang, T. Zang, E. M. Stevenson, X. Lei, D. C. Copertino, T. M. Mota, J. Boucau, W. F. Garcia-Beltran, R. B. F. Jones, P. D. Bieniasz
This study identifies ORF7a proteins from sarbecoviruses as inhibitors of MHC-I antigen presentation, with a single amino acid difference affecting their function.
bioRxiv · May 25, 2022Microbiology