X. Lei

Genetic variation in the species Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis

This study identifies natural heat resilience factors in Arabidopsis thaliana that enhance meiotic stability under heat stress, with implications for crop breeding.

Ultraviolet attenuates centromere-mediated meiotic genome stability and alters gametophytic ploidy consistency in flowering plants

This study shows UV radiation reduces crossover rates and disrupts meiotic spindle organization in Arabidopsis, leading to unreduced gametes and altered genome stability.

The paralogues MAGOH and MAGOHB are oncogenic factors in high-grade gliomas and safeguard the splicing of cell division and cell cycle genes

This study identifies MAGOH and MAGOHB as oncogenic factors in high-grade gliomas that safeguard splicing of cell division and cell cycle genes, with high expression linked to poor prognosis.

Perception of Motion Salience Shapes the Emergence of Collective Motions

The paper investigates collective motion patterns in bird flocks and develops a model based on motion salience to explain hierarchy formation and swarm behavior.

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.

This study shows HIRA and PML regulate SASP through interactions with p62/SQSTM1 and the cGAS-STING pathway in senescent cells.

Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

High Density Domain-Focused CRISPR Screens Reveal Novel Epigenetic Regulators of HOX/MEIS Activation in Acute Myeloid Leukemia

The paper identifies SGF29 as a novel chromatin regulator of MEIS1 and AML oncogenes, showing its role in leukemogenesis and potential as a drug target.

A unified model for the dynamics of ATP-independent ultrafast contraction

This study develops a minimal mathematical model to explain ultrafast contraction in ciliated protists, identifying three dynamic regimes based on chemical driving rates and inertia.

Initiation of HIV-1 Gag lattice assembly is required for cytoplasmic recognition of the viral genome packaging signal

This study shows that the assembly of an immature Gag lattice is necessary for specific binding of Gag to the HIV-1 RNA packaging signal.

Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

Preferential cross-linking of the stereospecific complex over the encounter complexes by DOPA2, a faster cross-linker than DSS

This study compares DOPA2 and DSS cross-linkers, finding that faster cross-linking favors the stereospecific complex over encounter complexes in transient protein interactions.

Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins

This study identifies ORF7a proteins from sarbecoviruses as inhibitors of MHC-I antigen presentation, with a single amino acid difference affecting their function.

An Igh novel enhancer modulates antigen receptor diversity by determining locus conformation

The paper identifies a novel enhancer, NE1, that modulates Igh locus conformation and influences V(D)J recombination by altering chromatin structure and VH gene usage.

Scalable production of recombinant three-finger proteins: from inclusion bodies to high quality molecular probes

This paper describes a scalable method for producing high-quality recombinant three-finger proteins using E. coli, enabling their use as molecular probes.

PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8+ T cells.

This study shows PSGL-1 modulates TCF-1/TOX axis to repress metabolism and promote T cell exhaustion in CD8+ T cells, making it a therapeutic target for PD-1/PD-L1 resistant tumors.

Metabolitin-based molecular drug delivery by targeting GPR158 in glioblastoma

This study develops a metabolitin-based drug delivery system targeting GPR158 in glioblastoma, showing BBB penetration and anti-tumor effects in vitro and in vivo.

ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

Identification of potent and safe antiviral therapeutic candidates against SARS-CoV-2

This study identifies 24 FDA-approved compounds that inhibit SARS-CoV-2 replication, with five showing high safety indices and blocking S protein-mediated cell fusion.

A Fast Lysine Cross-linker DOPA Enables Mass Spectrometry Analyses of Protein Unfolding and Weak Protein-protein Interactions

This study introduces a fast lysine cross-linker DOPA for mass spectrometry analyses, showing it enables rapid protein cross-linking and captures dynamic conformational changes and weak protein-protein interactions.

BRD4-mediated repression of p53 is a target for combination therapy in AML

This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.

A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AML

This study identifies JAK1 as a therapeutic target in AF10-rearranged AML by showing its role in JAK/STAT-mediated inflammatory signaling and oncogenesis.

Single-cell transcriptional atlas of the Chinese horseshoe bat (Rhinolophus sinicus) provides insight into the cellular mechanisms which enable bats to be viral reservoirs

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

Click-ExM enables expansion microscopy for all biomolecules

Click-ExM expands super-resolution imaging to all biomolecules by integrating click-labeling into expansion microscopy.

Modern human origins: multiregional evolution of autosomes and East Asia origin of Y and mtDNA

The paper challenges the Recent Out of Africa model by proposing multiregional evolution of autosomes and East Asian origin of modern Y and mtDNA through hybridization with archaic humans.

Inhibiting TG2 sensitize lung cancer to radiotherapy through interfering TOPOIIα-mediated DNA repair

This study shows that inhibiting TG2 increases radiosensitivity in NSCLC by disrupting TOPOIIα-mediated DNA repair.

Ancient DNAs and the Neolithic Chinese super-grandfather Y haplotypes

The paper analyzes ancient DNA from 12 Neolithic Chinese samples to explore relationships between Y haplotypes and archaeological records, finding close links between certain haplotypes and specific cultural groups.

Genetic continuity in the last seven Millennia in human hepatitis B viruses

The paper analyzes ancient and present-day HBV genomes to reconstruct the evolutionary history of hepatitis B virus, identifying genotype G in ancient isolates and placing genotype D as the most basal branch.

Accumulation of Minor Alleles of Common SNPs in Schizophrenia

The paper investigates the role of minor alleles in schizophrenia using public datasets, finding higher minor allele content in cases and identifying SNPs that predict schizophrenia with 100% certainty.