Evolution of a Plasmid Regulatory Circuit Ameliorates Plasmid Fitness Cost
C. A. Elg, E. Mack, M. Rolfsmeier, T. C. McLean, O. Kosterlitz, E. Soderling, S. Narum, P. A. Rowley, C. M. Thomas, E. M. Top
This study shows that inactivating the upf31 gene in a plasmid improves its maintenance in E. coli by altering gene regulation, demonstrating how plasmid evolution can affect host range.
bioRxiv · Feb 5, 2024Microbiology