Single cell RNA-seq uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19
M. Aznaourova, N. Schmerer, H. Janga, Z. Zhang, K. Pauck, J. Hoppe, S. M. Volkers, D. Wendisch, P. Georg, M. Guendisch, E. Mack, C. Skevaki, C. Keller, C. Bauer, W. Bertrams, , L. N. Schulte
The paper identifies PIRAT, a lncRNA regulating monocyte immunity in COVID-19 via PU.1 feedback, and shows its role in alarmin production.
bioRxiv · Nov 5, 2021 · PreprintImmunology