Author

C. Ruppert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. Guenther· 3 shared I. Shalashova· 2 shared P. Mahavadi· 2 shared R. M. Wasnick· 2 shared S. Bellusci· 2 shared A. D. Gruber· 1 shared A. L. Coelho· 1 shared A. Nist· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

A. Guenther

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pre-clinical proof-of-concept of anti-fibrotic activity of caveolin-1 scaffolding domain peptide LTI-03 in ex vivo precision cut lung slices from patients with Idiopathic Pulmonary Fibrosis

B. MacKenzie, P. Mahavadi, Y. A. P. Jannini-Sa, B. Creyns, A. L. Coelho, M. Espindola, C. Ruppert, K. Hoetzenecker, C. M. Hogaboam, A. Guenther

This study evaluates the anti-fibrotic effects of LTI-03 in IPF patient-derived precision cut lung slices, showing dose-dependent reduction of fibrotic markers.

bioRxiv · Apr 24, 2024 · PreprintPharmacology & Toxicology

Cell-surface PD-L1 expression identifies a sub-population of distal epithelial cells enriched in idiopathic pulmonary fibrosis

N. Ahmadvand, G. Carraro, M. Jones, I. Shalashova, J. Wihelm, N. Baal, F. Kosravi, C. Chen, J. Zhang, A. Guenther, R. M. Wasnick, S. Bellusci, C. Ruppert

The paper identifies CD274-expressing cells in human lungs that are expanded in IPF and show progenitor-like behavior in ex vivo assays.

bioRxiv · Mar 9, 2022 · PreprintCell Biology

Single cell RNA-seq uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

M. Aznaourova, N. Schmerer, H. Janga, Z. Zhang, K. Pauck, J. Hoppe, S. M. Volkers, D. Wendisch, P. Georg, M. Guendisch, E. Mack, C. Skevaki, C. Keller, C. Bauer, W. Bertrams, , L. N. Schulte

The paper identifies PIRAT, a lncRNA regulating monocyte immunity in COVID-19 via PU.1 feedback, and shows its role in alarmin production.

bioRxiv · Nov 5, 2021 · PreprintImmunology

Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition

R. M. Wasnick, M. Korfei, K. Piskulak, I. Henneke, J. Wilhelm, P. Mahavadi, D. von der Beck, M. Koch, I. Shalashova, O. Klymenko, L. Fink, H. Witt, H. Hackstein, E. El Agha, S. Bellusci, , A. Guenther

Notch1 inhibition restores alveolar epithelial differentiation, reduces surface tension, and reverses matrix deposition in lung fibrosis.

bioRxiv · Mar 23, 2019 · PreprintCell Biology