Long range allostery mediates the regulation of plasminogen activator inhibitor 1 by vitronectin
K. Kihn, E. Marchiori, G. Spagnolli, A. Boldrini, L. Terruzzi, D. A. Lawrence, A. Gershenson, P. Faccioli, P. L. Wintrode
This study uses simulations to show vitronectin regulates PAI-1 latency transition by reducing RCL and gate mobility through long-range allostery, revealing a cryptic drug binding site.
bioRxiv · Jul 19, 2022 · PreprintBiophysics