Author

D. A. Lawrence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Ashkenazi· 2 shared A. Le Thomas· 2 shared J. M. Harnoss· 2 shared S. A. Marsters· 2 shared A. Boldrini· 1 shared A. Gershenson· 1 shared A. Gogineni· 1 shared A. Heidersbach· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

A. Ashkenazi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Long range allostery mediates the regulation of plasminogen activator inhibitor 1 by vitronectin

K. Kihn, E. Marchiori, G. Spagnolli, A. Boldrini, L. Terruzzi, D. A. Lawrence, A. Gershenson, P. Faccioli, P. L. Wintrode

This study uses simulations to show vitronectin regulates PAI-1 latency transition by reducing RCL and gate mobility through long-range allostery, revealing a cryptic drug binding site.

bioRxiv · Jul 19, 2022 · PreprintBiophysics

Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability

L. M. Haynes, Z. M. Huttinger, A. Yee, C. A. Kretz, D. R. Siemieniak, D. A. Lawrence, D. Ginsburg

The paper analyzes PAI-1 variants to identify mutations that increase functional stability and inhibitory activity, and develops a method to measure functional half-lives of hundreds of variants in parallel.

bioRxiv · Jul 19, 2022 · PreprintBiochemistry

Altered meningeal immunity contributing to the autism-like behavior of BTBR T+ Itpr3tf/J mice.

D. A. Lawrence, M. N. Uddin, K. Manley

This paper investigates altered meningeal immunity in BTBR mice, linking immune changes to autism-like behaviors through neuroinflammation and autoantibody production.

bioRxiv · Jan 29, 2022 · PreprintImmunology

Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells

O. Guttman, A. Le Thomas, S. A. Marsters, D. A. Lawrence, L. Gutgesell, J. M. Harnoss, S. M. Haag, A. Murthy, G. Strasser, Z. Modrusan, T. Wu, I. Mellman, A. Ashkenazi

The paper shows antigen-derived peptides activate IRE1α in dendritic cells, reducing MHC-I expression and cross-presentation, and demonstrates that IRE1 inhibition enhances anti-tumor immunity.

bioRxiv · Sep 10, 2021Cell Biology

Disruption of IRE1α through its Kinase Domain Attenuates Multiple Myeloma

J. M. Harnoss, A. Le Thomas, S. A. Marsters, D. A. Lawrence, M. Lu, Y.-C. A. Chen, J. Qing, K. Totpal, D. Kan, E. Segal, H. Ackerly Wallweber, W. Wang, K. Clark, S. Kaufman, M. Beresini, , A. Ashkenazi

This study shows that disrupting IRE1α's kinase domain reduces multiple myeloma tumor growth and enhances treatment efficacy, suggesting it as a therapeutic target.

bioRxiv · Dec 14, 2018 · PreprintCancer Biology