Author

P. L. Wintrode

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Gershenson· 2 shared A. Boldrini· 1 shared D. A. Lawrence· 1 shared D. Deredge· 1 shared D. N. Hebert· 1 shared E. Marchiori· 1 shared G. Spagnolli· 1 shared H. Ke· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

A. Gershenson

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2 papers

Recent·Most cited

The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control

U. Kaur, K. C. Kihn, H. Ke, W. Kuo, L. M. Gierasch, D. N. Hebert, P. L. Wintrode, D. Deredge, A. Gershenson

This paper investigates how the N-terminal subdomain of serpin 1-antitrypsin (AAT) influences folding and in-cell quality control by maintaining a dynamic conformational landscape.

bioRxiv · Apr 24, 2023 · PreprintBiophysics

Long range allostery mediates the regulation of plasminogen activator inhibitor 1 by vitronectin

K. Kihn, E. Marchiori, G. Spagnolli, A. Boldrini, L. Terruzzi, D. A. Lawrence, A. Gershenson, P. Faccioli, P. L. Wintrode

This study uses simulations to show vitronectin regulates PAI-1 latency transition by reducing RCL and gate mobility through long-range allostery, revealing a cryptic drug binding site.

bioRxiv · Jul 19, 2022 · PreprintBiophysics